Epithelial Barrier Theory

Key Publications


Losol P, Sokolowska M, Hwang YK, et al. Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases. Allergy Asthma Immunol Res.

26 October 2023

Jutel, MAgache, IZemelka-Wiacek, M, et al. Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paperAllergy.

10 October 2023

Rinaldi, AOLi, MBarletta, E, et al. Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skinAllergy

27 September 2023

Saito K, Orimo K, Kubo T, et al. Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s. Allergy.

10 May 2023

Kıykım A, Ogulur İ, Yazıcı D, et al. Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis. Turk Arch Pediatr.

01 March 2023

Yazici D, Pat Y, Mitamura Y, Akdis CA, Ogulur I. Detergent-induced eosinophilic inflammation in the esophagus: A key evidence for the epithelial barrier theory. Allergy.

16 January 2023

Ogulur I, Pat Y, Aydin T, et al. Gut epithelial barrier damage caused by dishwasher detergents and rinse aids. J Allergy Clin Immunol.

01 December 2022

Pat Y, Ogulur I, Yazici D, et al.  Effect of altered human exposome on the skin and mucosal epithelial barrier integrity. Tissue Barriers

19 October 2022

Celebi Sozener Z, Özbey Yücel Ü, Altiner S, et al. The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis. Front Allergy

08 July 2022

D’Amato G, Akdis CA. Desert dust and respiratory diseases: Further insights into the epithelial barrier hypothesis. Allergy

27 May 2022

Pat Y, Rückert B, Ogulur I, et al. Differentiation of bronchial epithelial spheroids in the presence of IL-13 recapitulates characteristic features of asthmatic airway epithelia. Allergy

10 March 2022

Dong X, Ding M, Zhang J, et al. Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma. Chin Med J (Engl). 

05 March 2022

Celebi Sozener Z, Ozdel Ozturk B, Cerci P, et al. Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease. Allergy.

02 February 2022

Fiorito S, Soligo M, Gao Y, et al. Is the epithelial barrier hypothesis the key to understanding the higher incidence and excess mortality during COVID-19 pandemic? The case of Northern Italy. Allergy.

31 January 2022

Akdis CA. The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic noncommunicable diseases. J Allergy Clin Immunol.

22 November 2021

Mitamura Y, Ogulur I, Pat Y, et al. Dysregulation of the epithelial barrier by environmental and other exogenous factors. Contact Dermatitis

17 September 2021

Akdis, C.A. Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?. Nat Rev Immunol.

12 April 2021

Rinaldi AO, Korsfeldt A, Ward S, et al. Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis. Allergy

08 April 2021

Angelina A, Martín-Fontecha M, Rückert B, et al.  The cannabinoid WIN55212-2 restores rhinovirus-induced epithelial barrier disruption. Allergy.

15 December 2020

Wawrzyniak P, Krawczyk K, Acharya S, et al.  Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma. Allergy

19 November 2020

Celebi Sözener Z, Cevhertas L, Nadeau K, Akdis M, Akdis CA. Environmental factors in epithelial barrier dysfunction. J Allergy Clin Immunol

24 April 2020

Sugita K, Soyka MB, Wawrzyniak P, et al. Outside-in hypothesis revisited: The role of microbial, epithelial, and immune interactions. Ann Allergy Asthma Immunol.

23 May 2020

Xian M, Ma S, Wang K, et al. Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells. Allergy Asthma Immunol Res.

30 August 2019

Sokolowska M, Quesniaux VFJ, Akdis CA,  et al. Acute Respiratory Barrier Disruption by Ozone Exposure in Mice. Front Immunol. 

13 September 2019

Steelant B, Wawrzyniak P, Martens K, et al. Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis. J Allergy Clin Immunol.

19 May 2019

Rinaldi AO, Morita H, Wawrzyniak P,  et al. Direct assessment of skin epithelial barrier by electrical impedance spectroscopy. Allergy

16 April 2019

Wang M, Tan G, Eljaszewicz A, et al. Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells. J Allergy Clin Immunol. 

27 November 2018

Michaudel C, Mackowiak C, Maillet I, et al. Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33. J Allergy Clin Immunol

10 January 2018

Jiao J, Wang M, Duan S, et al. Transforming growth factor-β1 decreases epithelial tight junction integrity in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 

10 November 2017

Steelant B, Seys SF, Van Gerven L, et al. Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis. J Allergy Clin Immunol. 

23 October 2017

Kast JI, McFarlane AJ, Głobińska A, et al. Respiratory syncytial virus infection influences tight junction integrity. Clin Exp Immunol.

05 October 2017

Sugita K, Steer CA, Martinez-Gonzalez I, Altunbulakli C, et al. Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients. J Allergy Clin Immunol.

06 April 2017

Steelant B, Seys SF, Boeckxstaens G, et al. Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease. Rhinology. 

September 2016

Wawrzyniak P, Wawrzyniak M, Wanke K, et al. Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients. J Allergy Clin Immunol. 

11 May 2016

Steelant B, Farré R, Wawrzyniak P, et al. Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression. J Allergy Clin Immunol.

02 February 2016

Kubo T, Wawrzyniak P, Morita H, et al. CpG-DNA enhances the tight junction integrity of the bronchial epithelial cell barrier. J Allergy Clin Immunol. 

19 June 2015

Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4. J Allergy Clin Immunol.

26 July 2012

Fujita H, Chalubinski M, Rhyner C,  et al. Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects. J Allergy Clin Immunol. 

June 2011

Mittermann I, Reininger R, Zimmermann M, et al. The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma. J Invest Dermatol. 

June 2008

Akdis, C.A., Allergy and hypersensitivity: Mechanisms of allergic disease, Current Opinion in Immunology.

9 October 2006