Epithelial Barrier Theory

Public Information

Epithelial barrier-damaging agents

Here is a list of epithelial barrier damaging substances with data developed from our labs.

  1. Air pollutants: Particulate matter, ozone, diesel exhaust, inhaled chlorine and household-cleaners and cigarette smoke can damage epithelial cells and disrupt barrier integrity.
  2. Household chemicals: Detergents, surfactants, and disinfectants used in laundry, dishwashers, and cleaning products can compromise epithelial barriers.
  3. Food additives: Emulsifiers and preservatives added to processed foods have been shown to impair epithelial barrier function.
  4. Microplastics: Tiny plastic particles can accumulate in tissues and disrupt epithelial barriers, leading to inflammation. Microplastics have been shown in amniotic fluid, pericardial fluid and coronary artery plaques.
  5. Nanoparticles: Some engineered nanomaterials can penetrate and damage epithelial cells and tight junctions.

Exposure to these epithelial barrier-disrupting agents trigger a cascade of events, including epithelial cell activation and barrier damage, microbial dysbiosis, inappropriate immune responses, and chronic inflammation, which contribute to the development of various chronic diseases.

Suggestions for the prevention of chronic diseases

How to Reduce Exposure to Epithelial Barrier-Damaging Agents in Homes:

Clean air is a basic right for life

  • Choose sodium lauryl sulphate free and fragrance-free and natural household cleaning products:
  • Avoid detergents, surfactants, and disinfectants that can compromise epithelial barrier integrity.
  • Look for cleaning products made with natural, gentle ingredients.
  • Vinegar is commonly used in many households and no unwanted or side effects have been reported.
  • Stay away from sodium lauryl sulphate containing products.

How to Reduce Plastic Waste at Home or Office:

  • Make a conscious effort to substitute plastic and disposable bottles with reusable glass containers for various household and office needs.
  • Opt for eco-friendly refill packs for soap, shampoo, and cleaning products instead of opting for disposable bottles.
  • Use brushes and sponges for dishwashing that are free from plastic.
  • Choose reusable water bottles over disposable plastic ones.
  • Carry your own reusable bags when going shopping to steer clear of plastic bags.

A Fresh Understanding of the Term “Harmful”

Epithelial barrier theory and the changing concept of chronic microtoxicity:

After the World War II and during the second Industrial Revolution, there was a significant surge in the prevalence of processed foods, cigarette smoke, and diesel emissions, coinciding with a revolutionary period in chemistry. This era also marked the commencement of our fascination with “cleanliness,” as chemical-based laundry and dishwasher detergents, household cleaning products, and even cosmetics made their debut. Since 1960, more than 350,000 new chemicals have been introduced into our environment, and a considerable number of these compounds remain undisclosed to the public. Approximately 50,000 are classified as confidential, while around 70,000 are described ambiguously.

Redefining Toxicity and Clean

Redefining toxicity to reimagine “clean” is an important concept, especially in the context of environmental sustainability, public health, and the products we use in our daily lives. Toxicity traditionally refers to the harmful or poisonous nature of substances, often associated with chemicals or pollutants that can have adverse effects on human health and the environment. However, redefining toxicity can involve several different aspects:

Expanding the Definition of Toxicity:

To reimagine “clean,” we can broaden our understanding of toxicity to include not only the immediate and obvious harms of chemicals but also their long-term and cumulative effects. This means considering the impacts of substances on ecosystems, biodiversity, and future generations.