Review Articles

Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs

Ardicli S, Ardicli O, Yazici D, et al.
Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs

The epithelial barrier theory and its associated diseases

Sun N, Ogulur I, Mitamura Y, et al.
The epithelial barrier theory and its associated diseases

Outside-in hypothesis revisited: The role of microbial, epithelial, and immune interactions

Sugita K, Soyka MB, Wawrzyniak P, et al. Ann Allergy Asthma Immunol.
Outside-in hypothesis revisited: The role of microbial, epithelial, and immune interactions

Environmental factors in epithelial barrier dysfunction

Celebi Sözener Z, Cevhertas L, Nadeau K, Akdis M, Akdis CA. J Allergy Clin Immunol.
Environmental factors in epithelial barrier dysfunction

Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Akdis, C.A.
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Dysregulation of the epithelial barrier by environmental and other exogenous factors

Mitamura Y, Ogulur I, Pat Y, et al. Contact Dermatitis.
Dysregulation of the epithelial barrier by environmental and other exogenous factors

The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic noncommunicable diseases

Akdis CA
The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic noncommunicable diseases

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Celebi Sozener Z, Ozdel Ozturk B, Cerci P, et al.
Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma.

Dong X, Ding M, Zhang J, et al.
Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma.

The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis.

Celebi Sozener Z, Özbey Yücel Ü, Altiner S, et al.
The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis.

Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis

Kıykım A, Ogulur I, Yazici D, et al.
Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis

The epithelial barrier theory: Development and exacerbation of allergic and chronic inflammatory diseases

Kucuksezer UC, Ozdemir C, Yazici D, et al.
The epithelial barrier theory: Development and exacerbation of allergic and chronic inflammatory diseases

Recent advances in the epithelial barrier theory

Pat Y, Yazici D, D’Avino P, et al.
Recent advances in the epithelial barrier theory

Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases

Losol P, Sokolowska M, Hwang YK, et al.
Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases

Epithelial barrier theory in the context of nutrition and environmental exposure in athletes

Kistler W, Villiger M, Villiger B, et al.
Epithelial barrier theory in the context of nutrition and environmental exposure in athletes

Effect of altered human exposome on the skin and mucosal epithelial barrier integrity

Pat Y, Ogulur I, Yazici D, et al.
Effect of altered human exposome on the skin and mucosal epithelial barrier integrity

The epithelial barrier hypothesis: a 20-year journey

Pat, Y. , Ogulur, I.
The epithelial barrier hypothesis: a 20-year journey

The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

Yazici, D., Ogulur, I., Pat, Y. et al.
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases ‍

‍Yazici, D., Ogulur, I., Kucukkase, O. et al.
Epithelial barrier hypothesis and the development of allergic and autoimmune diseases ‍

The Epithelial Barrier Theory is a comprehensive explanation for the global, epidemic-level rise in chronic health conditions over the past 65 years. The theory, postulated by Akdis, proposes that exposure to toxic substances introduced by industrialization and modern lifestyle changes disrupts the epithelial barrier of the skin, upper and lower airways, and gut mucosa and causes microbial dysbiosis triggering an inflammatory immune response that can initiate or aggravate many chronic inflammatory diseases.